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. Author manuscript; available in PMC: 2021 Jul 30.
Published in final edited form as: Bioorg Chem. 2020 Mar 20;99:103778. doi: 10.1016/j.bioorg.2020.103778

Figure 8.

Figure 8

Immune-histological analysis of p-c-MET (A) and human Ki-67 (B) expression after oral treatment with prodrug A or crizotinib. H1993 cells were injected s.c. into SCID mice. After the tumor reached a length of ~10 mm, 89.2 mg/kg prodrug A, 50 mg/kg crizotinib or solvent were administered p.o.. After 24 h, tumors were paraffin-embedded and stained as described in the M&M section. Evaluation of the stain was performed by Definiens software. Significance was calculated compared to solvent controls with unpaired t-test (no significance was reached).