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. Author manuscript; available in PMC: 2021 Aug 2.
Published in final edited form as: Cancer Res. 2020 Mar 11;80(8):1735–1747. doi: 10.1158/0008-5472.CAN-19-1372

Figure 7. Proposed model showing a potential mechanism for the synthetic lethal interaction between B-family DNA polymerase and CHK1 inhibition.

Figure 7

Schematic illustrating the DNA replication fork under unperturbed conditions, after pharmacological inhibition of B family DNA polymerases, and following combined pharmacological inhibition of B-family DNA polymerase and CHK1.