Table 1. Clinical characteristics and laboratory findings in patients with ZNF384 gene rearrangements.
UPN.NO | Age/ Sex | Total WBC (/cu.mm) | Blast (%) | CD10 (%) | CD13 (%) | CD33 (%) | Karyotype | Fusion partner (RT-PCR) | End Induction MRD |
---|---|---|---|---|---|---|---|---|---|
FS 39/19 | 59/M | 16 900 | 94 | 37.7 | 66.4 | 93.1 | 46,XY,t(12;17)(p13.3;q11.2) [16]/ 47,idem,+8[4] | TAF15 | Positive (0.202%) |
FS 42/19 | 33/M | 6200 | 29 | 34.1 | 61.6 | 85 | 46,XY,add(7)(p11.1),del(7) (p11.1)[12]/46,XY[8] | TCF3 FISH only | aNot applicable |
FS 52/19 | 23/M | 34 000 | 88 | 47.6 | 60.4 | 15 | 46,XY[20] | EP300 | Positive (0.411%) |
FS 84/19 | 13/F | 11 100 | 56 | 58 | 1.7 | 91.1 | 46,XX,del(7)(q22)[9]/ 46,XX[11] | EP300 | Positive (1.735%) |
FS 62/19 | 2/M | 10 100 | 79 | 44.1 | 13.5 | 84.4 | 46,XY[20] | EP300-FISH only | aNot applicable |
F1002/19 | 9/F | 18 600 | 83 | 11.8 | 94.8 | 97.1 | 46,XX[20] | EP300 | Positive (0.500%) |
FS124/19 | 2/M | 45 700 | 73 | 55.2 | 73.9 | 17.5 | 46,XY[22] | EP300 | Negative |
FS04/20 | 25/M | 12 100 | 39 | 1.7 | 21.9 | 86.7 | 46 ~ 47,XY,del(1)(q32),?der (16), add(17)(q25), -20,+mar, +mar [cp7]/ 46,XY[19] | EP300 | Positive (2.247%) |
FS113/20 | 48/M | 3200 | 96 | 17.9 | 90.4 | 80.4 | 46,XY,t(2;5)(p12;q35), del(13) (q13q32)[15]/ 46,XY[5] | EP300 | Negative |
FS124/20 | 22/M | 5400 | 61 | 43.1 | 44.5 | 84.6 | 46,XY[20] | EP300 | Negative |
FS125/20 | 52/M | 2000 | 90 | 7.5 | 42.3 | 83.9 | 46,XY,add(20)(q13.3) [2]/ 46,XY[18] | EP300-FISH only | Not available |
FS127/20 | 20/F | 5500 | 92 | 56.9 | 6.9 | 70.9 | 46,XX,ins(5;13) (q31;q13q33) [11]/ 46,XX[9] | EP300 | aNot applicable |
FS162/20 | 41/F | 9100 | 82 | 0.3 | 46.8 | 86.4 | 46,XX[21] | EP300 | Positive (0.463%) |
FL 54/20 | 33/M | 16 900 | 97 | 14 | 52.2 | 51 | 47,XY,+X[11]/48,idem, +12[4]/46,XY[6] | EP300-FISH only | aNot applicable |
Note: Abbreviations: CD, Cluster of differentiation; MRD, Measurable residual disease; RT-PCR, Reverse transcriptase-polymerase chain reaction; WBC, White blood cell.
Patients who discontinued treatment at the study center.