Figure 6. Sex-based differences of molecular mechanisms of anticancer immune response and immune evasion.

Figure shows sex-based differences in key features of anticancer immune response and in mechanisms exploited by tumors to evade immune system, described in this work, as well as differences in effectiveness of different immunotherapeutic strategies, demonstrated in previous works.

Features explored are represented as bars, and colors indicate their higher prevalence/enrichment in females (red bars) or in male patients (blue bars).

The bell curve represents sex-based dimorphism of specific elements of each of the features explored: elements with higher prevalence/enrichment in females are represented in red and on the right of the bell curve, while elements with higher prevalence/enrichment in males are represented in blue and on the left.