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. Author manuscript; available in PMC: 2022 Aug 5.
Published in final edited form as: Cell Stem Cell. 2021 Apr 9;28(8):1362–1379.e7. doi: 10.1016/j.stem.2021.03.004

Figure 2. ZIKV and HSV-1 infections elicit distinct transcriptional responses.

Figure 2

A-B) Graphs showing the number of differentially expressed genes (DEGs) in virus-infected organoids.

C) Top 10 Gene Ontology (GO)-terms of downregulated genes (log2FoldChange <1) in ZIKV vs. MOCK-exposed organoids (12 dpi).

D) Venn diagram showing limited overlap between the two datasets.

E and H) Top 10 GO-terms of upregulated genes (log2FoldChange >2) in virus-infected organoids (12 dpi in E, 8 dpi in H).

F and I) Top 10 results of ChEA3 transcription factor (TF) analysis performed on upregulated genes.

G and J) Expression of the top 25 upregulated genes in ZIKV-infected organoids (12 dpi, in G) or in HSV-1-infected organoids (8 dpi, in J). FC, fold change.

K-M) Immunostaining (scale bars 50 μm in K-L, 20 μm in M) of infected and MOCK-treated organoids. Dashed lines and asterisks indicate organoid surface based on DAPI signal (not shown) and lumen respectively.

dpi, days post-infection. See also Figure S2 and Table S3.