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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: Nature. 2020 Dec 2;588(7838):515–520. doi: 10.1038/s41586-020-2990-5

Extended Data Figure 3. Annotated sequence alignment of heavy chains of human non-muscle myosin 2A (NM2A) and smooth muscle myosin (SmM) with Turkey SmM, showing sites of mutation.

Extended Data Figure 3

HsNM2A: Homo sapiens MYH9; MgSmM: Meleagris gallopavo MYH11; HsSmM: Homo sapiens MYH11. Boxes delimit structural features. Grey background identifies residues in the d position of the coiled coil heptad repeat. Skip residues and bend positions are highlighted. Arrowheads and magenta letters denote known sites of mutation, obtained from the Human Genome Mutation Database (HGMD), Variant of unknown significance: retrieved from the Leiden mutation database.