Skip to main content
. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: Nat Metab. 2021 Aug 2;3(8):1071–1090. doi: 10.1038/s42255-021-00432-5

Figure 7. Loss of LepR expression in median eminence tanycytes alters adrenergic receptor expression in the pancreas and impairs cold-mediated increases in noradrenaline.

Figure 7

(A) Serum noradrenaline concentrations in LepR loxP/loxP and LepR TanKO mice, 12 weeks after TAT-Cre infusion. Two-sided unpaired Student’s t-test. Values indicate means ± SEM; each dot represents a mouse (n=7,8).

(B) Relative mRNA expression levels of adrenergic receptors in isolated pancreatic islets from LepR loxP/loxP and LepR TanKO mice, 12 weeks after TAT-Cre infusion. Two-sided unpaired Student’s t-test. Values indicate means ± SEM; each dot represents a mouse (n=4 in each group).

(C) Rectal temperature mesured in LepR loxP/loxP and LepR TanKO mice, 12 weeks after TAT-Cre infusion, before and after 2h cold exposure. Two-sided paired Student’s t-test. Values indicate means ± SEM; each dot represents a mouse (n=8,8,6,6).

(D) Ratio between the delta temperature after-before cold exposure to the serum noradrenaline concentration after cold exposure from LepR loxP/loxP and LepR TanKO mice. Two-sided unpaired Student’s t-test. Values indicate means ± SEM; each dot represents a mouse (n=8,6).