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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Anal Chem. 2021 May 20;93(21):7616–7624. doi: 10.1021/acs.analchem.1c00119

Table 3. Precision versus retention time and peak areaa .

Non-matching A/IS Matching A/IS
Platform Δ retention timeb retention timec peak aread Δ peak areae
rho p-value rho p-value rho p-value rho p-value
GC 0.54 < 0.001 −0.08 0.7 −0.15 < 0.001 0.14 < 0.001
LC1 0.17 < 0.001 0.01 1 −0.57 < 0.001 0.2 < 0.001
LC2 0.24 < 0.001 0.05 0.8 −0.37 < 0.001 0.02 0.6
LC3 0.93 < 0.001 −0.09 0.9 −0.48 < 0.001 0 0.9
a

Results of Spearman’s correlation analyses.

b

CV vs the absolute difference in retention time between analyte and all non-matching IS.

c

CV vs the mean retention time for analyte and matching IS

d

CV vs the harmonic mean (emphasizing the smaller value) peak area of each matching A/IS pair.

e

CV vs the absolute difference in peak are between analyte and IS. The two latter correlations were performed with mutual adjustment. Abbreviations A, analyte, IS, internal standard.