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Mean concentrations of leukocyte, immunoglobulin-G, haptoglobin, and uric acid during the 20 years before the diagnosis of amyotrophic lateral sclerosis and Parkinson’s disease, comparing patients (solid line) to matched controls (dashed line). Locally weighted scatterplot smoothing was used to produce smooth curves for the mean concentrations based on all available measurements during the 20-years period, for both the cases and their matched controls.
