Table 3. Multinomial logistic regression of comorbidities at 18 months, 3 years, 5 years and 8 years with AD trajectories^a .

	Early onset transient		Early onset persistent		Late onset persistent
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
18 months (n=548)
HDM sensitization	3.15 (1.4-7.06)	0.005	3.13 (0.76-12.97)	0.115	1.6 (0.6-4.23)	0.346
Food sensitization	2.94 (0.83-10.45)	0.096	16.94 (3.14-91.35)	0.001	1.67 (0.32-8.79)	0.546
AR	1.1 (0.4-3.05)	0.853	1.41 (0.23-8.57)	0.709	1.57 (0.62-4.01)	0.343
Wheezing	1.04 (0.25-4.3)	0.961	0 (0-.c)	0.995	2.02 (0.56-7.33)	0.285
36 months (n=524)
HDM sensitization	4.34 (2.25-8.4)	<0.001	1.55 (0.43-5.59)	0.506	1.95 (0.96-3.96)	0.066
Food sensitization	NA	NA	NA	NA	NA	NA
AR	2.11 (0.98-4.57)	0.057	0.58 (0.1-3.36)	0.54	2.55 (1.2-5.42)	0.015
Wheezing	2.65 (1.09-6.47)	0.032	2.41 (0.49-11.77)	0.276	3.84 (1.64-8.99)	0.002
60 months (n=482)
HDM sensitization	2.28 (1.1-4.73)	0.027	1.61 (0.39-6.67)	0.514	4.77 (2.2-10.35)	<0.001
Food sensitization	1.36 (0.32-5.88)	0.679	24.6 (3.97-152.43)	0.001	1.37 (0.35-5.41)	0.655
AR	1.48 (0.46-4.76)	0.511	0.25 (0.02-3.47)	0.301	1.27 (0.38-4.28)	0.697
Wheezing	2.82 (1.09-7.29)	0.033	1.69 (0.29-9.94)	0.562	0.33 (0.07-1.57)	0.165
8 yearsb
Current AR (n=462)	1.19 (0.56-2.52)	0.656	0.75 (0.17-3.34)	0.71	2.52 (1.14-5.57)	0.022
Current wheezing (n=462)	3.9 (1.44-10.61)	0.008	27.27 (4.61-161.42)	<0.001	1.39 (0.34-5.71)	0.645
Any sensitization (n=462)	2.06 (0.99-4.28)	0.053	2.35 (0.55-9.97)	0.248	2.27 (1-5.16)	0.051
Any HDM sensitization (n=462)	2.09 (1-4.35)	0.05	2.38 (0.56-10.14)	0.241	2.28 (1-5.19)	0.05
Any food sensitization (n=463)	2.44 (0.92-6.46)	0.072	4.66 (0.84-25.72)	0.077	2.09 (0.67-6.51)	0.205
Current AR + sensitization (n=478)	0.91 (0.38-2.18)	0.831	0.8 (0.19-3.46)	0.768	3.53 (1.58-7.88)	0.002
Current wheezing + sensitization (n=223)	9.35 (1.87-46.91)	0.007	696.56 (1.99-243432.57)	0.028	9.1 (1.24-66.84)	0.03
Persistent AR (n=365)	1.54 (0.58-4.14)	0.389	0.63 (0.03-12.66)	0.761	5.35 (1.87-15.35)	0.002
Persistent AR + sensitization (n=376)	1.63 (0.51-5.2)	0.408	1.11 (0.06-20.23)	0.946	4.94 (1.53-15.91)	0.007

^aAll analyses were adjusted for prenatal and environmental factors shown in Figure 3, including pet ownership, household smoking, childcare attendance and infant’s use of antibiotics during the first year. All comparisons were made with the non-AD group as the reference group.

^bFor this model, multinomial logistic regressions were carried out stepwise adding each non-overlapping variable to the model separately. This was repeated until all the variables were included in a model. As a result, the numbers included in each analysis vary as shown in the table.

AR: Allergic Rhinitis; HDM: House dust mite; NA: Not applicable

Any sensitization: positive skin prick test result to any of the house dust mite allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis), food allergens (egg, peanut, cow’s milk, shrimp, crab) or aeroallergens (Blatella germanica and Periplanata Americana).