Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nature. 2021 Mar 10;592(7852):80–85. doi: 10.1038/s41586-021-03345-1

Figure 1. The genomes of bulk placental biopsies.

Figure 1

(a) Workflow detailing experimental design with a photomicrograph demonstrating microdissection of placental tissue. (b) Substitution burden per bulk placental sample, adjusted for coverage and median VAF (Methods). An abnormal pregnancy is defined by the deviation of one or more clinically validated markers from their normal range over the course of pregnancy (Supplementary Tables 2-3). (c) Median VAF of substitutions in each bulk placental sample. (d) SBS signatures in placental biopsies. Each column represents one bulk sample. Colours represent signatures, as per legend. (e) Prevalence of SBS18 mutations in bulk placental biopsies in comparison to human intestinal tissue12, the normal tissue with the highest prevalence of SBS18 reported to date. P-values refer to the two-sided Wilcoxon rank sum test.