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Insulin stimulation (15 minutes) causes a dose dependent increase in PKB/akt phosphorylation in differentiated chub-S7 cells (A). Dexamethasone pre-treatment (1μM, 48hrs), does not change IRS1 (B) or PKB/akt protein expression (C), but enhances insulin stimulated phosphorylation (B and C). (C=control, D=dexamethasone, representative Western blots are shown with the quantification relative to β-actin of n=3-5 experiments shown below, * p<0.05 vs. control)
