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. Author manuscript; available in PMC: 2021 Dec 21.
Published in final edited form as: Nat Genet. 2021 Jun 21;53(7):1022–1035. doi: 10.1038/s41588-021-00887-y

Extended Data Fig. 10. HIF-1 and H3K4me3 ChIP-seq examples.

Extended Data Fig. 10

(a-c) HIF-1α, HIF1β, and H3K4me3 ChIPsequencing in wildtype, HIF1β and SET1B mixed population knockout HeLa cells treated with 21% or 1% O2 for 6 h. Analysis of H3K4me3 peaks using the IGV genome browser for normalised reads at specific genomic regions. Selected HIF target angiogenesis genes (a), HIF target glycolysis genes (b), and the non-HIF target BAP1 (c) are shown. Arrows indicate the directionality of the gene of interest, black box highlights region where H3K4me3 varies.