Table 2. Biomarkers and Principal Components associated with HCLD.
| Univariate OR (95% CI, P) | Adjusted OR (95% CI, P) | |
|---|---|---|
| MMP-1 | 1.41 (1.09-1.84, p= .009) | 1.36 (1.04-1.79, p= .028) |
| MMP-7 | 1.52 (1.18-1.98, p=0= .001) | 1.42 (1.07-1.90, p= .015) |
| MMP-10 | 1.70 (1.29-2.25, p< .001) | 1.61 (1.20-2.19, p= .002) |
| Angiopoietin-1 | 1.49 (1.19-1.90, p= .001) | 1.53 (1.20-1.96, p= .001) |
| sCCL5 | 1.36 (1.06-1.75, p= .015) | 1.37 (1.05-1.80, p= .023) |
| sCD14 | 1.96 (1.51-2.57, p< .001) | 2.23 (1.66-3.05, p< .001) |
| sCD25 | 2.74 (2.01-3.81, p< .001) | 2.85 (2.00-4.19, p< .001) |
| sCD27 | 2.26 (1.65-3.16, p< .001) | 2.05 (1.48-2.91, p< .001) |
| sCD40-Ligand | 2.89 (2.12-4.06, p< .001) | 2.96 (2.12-4.25, p< .001) |
| CRP | 1.55 (1.20-2.04, p= .001) | 1.48 (1.12-1.98, p= .006) |
| IP-10/CXCL10 | 1.93 (1.42-2.69, p< .001) | 1.89 (1.36-2.72, p< .001) |
| D-Dimer + | 1.68 (1.27-2.25, p< .001) | 1.68 (1.25-2.29, p= .001) |
| E-Selectin | 2.08 (1.57-2.81, p< .001) | 2.05 (1.52-2.82, p< .001) |
| FAS | 1.59 (1.23-2.08, p= .001) | 1.59 (1.21-2.12, p= .001) |
| GCSF | 0.75 (0.58-0.97, p= .032) | 0.68 (0.50-0.91, p= .010) |
| IFN-γ | 1.75 (1.35-2.28, p< .001) | 2.63 (1.77-4.12, p< .001) |
| VCAM-1 | 1.70 (1.29-2.30, p< .001) | 1.56 (1.18-2.10, p= .003) |
| VEGF | 0.79 (0.61-1.02, p= .070) | 0.73 (0.55-0.95, p= .022) |
| PC1 | 1.60 (1.39-1.85, p< .001) | 1.54 (1.33-1.80, p<0.001) |
| PC3 | 1.39 (1.15-1.70, p= .001) | 1.44 (1.16-1.81, p=0.001) |
| PC4 | 0.68 (0.56-0.83, p< .001) | 0.62 (0.49-0.77, p<0.001) |
| PC5 | 0.77 (0.62-0.96, p= .022) | 0.71 (0.54-0.92, p=0.012) |
| PC6 | 0.77 (0.61-0.96, p= .020) | 0.74 (0.58-0.94, p=0.014) |
| PC7 | 1.28 (1.00-1.64, p= .053) | 1.47 (1.11-1.95, p=0.007) |
Odds ratios represent change in odds per one standard deviation increase in biomarker. Adjusted models include Age, Sex, Study site, Height for age z-scores, HIV viral suppression and having ever been treated for TB. Only biomarkers with p < .05 in adjusted analysis are shown.