Table 3. Biomarkers associated with lung function in HCLD+ participants.
| Univariate β ± SE | P-Value | Adjusted β ± SE | P-Value | |
|---|---|---|---|---|
| MMP-8 | -0.122 ± 0.039 | .002 | -0.097 ± 0.039 | .012 |
| MMP-10 | -0.161 ± 0.038 | <.001 | -0.132 ± 0.04 | .001 |
| ANG-1 | 0.08 ± 0.039 | .041 | 0.077 ± 0.039 | .046 |
| CRP | -0.149 ± 0.038 | <.001 | -0.128 ± 0.038 | .001 |
| IP-10 | -0.089 ± 0.039 | .023 | -0.08 ± 0.04 | .048 |
| E-Selectin | -0.104 ± 0.039 | .008 | -0.082 ± 0.039 | .037 |
| Fas | 0.083 ± 0.039 | .035 | 0.082 ± 0.039 | .033 |
| GCSF | -0.106 ± 0.039 | .007 | -0.11 ± 0.039 | .006 |
| VCAM-1 | -0.105 ± 0.039 | .007 | -0.09 ± 0.039 | .021 |
| VEGF | -0.117 ± 0.039 | .003 | -0.113 ± 0.039 | .004 |
| PC1 | -0.053 ± 0.017 | .002 | -0.044 ± 0.018 | .014 |
| PC4 | 0.084 ± 0.03 | .005 | 0.096 ± 0.03 | .001 |
| PC5 | -0.105 ± 0.033 | .002 | -0.092 ± 0.036 | .011 |
| PC7 | 0.083 ± 0.038 | .029 | 0.082 ± 0.038 | .031 |
Linear Regression of log10 scaled biomarkers and FEV1 z-score in the HCLD group. Covariates included age, sex, having ever been treated for TB, study site, height for age z-score and supressed viral load. Only biomarkers with statistically significant associations (p < .05) are shown. β = coefficient