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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nat Ecol Evol. 2021 May 17;5(7):1033–1045. doi: 10.1038/s41559-021-01456-6

Figure 6. Phylogenetic trees and tumour maps showing the inferred clonal expansion pattern and tumour metastasising routes.

Figure 6

A) Most cases had a contiguous clonal expansion, while one case of clonal dispersal was seen in 2 out of 79 samples. B) A tumour map and a phylogenetic tree of case K096 showing a pattern of contiguous clonal expansion. C) Tumour maps and phylogenetic trees of cases G_K234 and D) K163 showing clonal dispersal (dotted line). In case K234, the dispersing clone formed the metastasising branch and gave rise to its descendant clone which was also found in a venous thrombus. In case K163, the dispersing clone wasn’t associated with metastasis.