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OT organelles are designed organelles enriched in a suppressor tRNA/tRNA synthetase pair and a specific mRNA binding domain (MCP) by means of using an assembler protein (such as FUS and/or KIFs). A spatially distinct set of ribosomes associated with the OT organelle preferentially translates recruited mRNAs tagged with ms2 loops to yield the selected protein with the targeted site-specific noncanonical functionality.
