Table 6. Multivariate associations between all maternal plasma metabolites and positive SPT at 18 months in the offspring.

	18 months (n=716)
	RR (95% CI)	p-value *
N1-methylnicotinamide		0.878
Lowest	1.0
2nd	0.97(0.53 – 1.76)	0.913
3rd	0.85(0.44 – 1.64)	0.630
Highest	1.1(0.6 – 2.2)	0.715
Nicotinamide		0.089
Lowest	1.0
2nd	1.6(0.8 – 3.0)	0.155
3rd	1.6(0.8 – 3.1)	0.162
Highest	1.8(0.9 – 3.6)	0.088
Trigonelline		0.477
Lowest	1.0
2nd	1.1(0.7 – 2.0)	0.633
3rd	1.1(0.6 – 1.9)	0.801
Highest	0.81(0.41 – 1.58)	0.530
3-Hydroxyanthranilic acid		0.183
Lowest	1.0
2nd	0.80(0.43 – 1.48)	0.477
3rd	0.96(0.52 – 1.75)	0.880
Highest	0.58(0.28 – 1.21)	0.147
3-Hydroxykynurenine		0.003
Lowest	1.0
2nd	1.2(0.6 – 2.3)	0.625
3rd	2.0(1.0 – 3.7)	0.042
Highest	2.6(1.3 – 5.2)	0.008
Anthranilic acid		0.713
Lowest	1.0
2nd	1.0(0.6 – 1.8)	0.990
3rd	0.61(0.31 – 1.19)	0.149
Highest	0.95(0.50 – 1.8)	0.873
Kynurenic acid		0.774
Lowest	1.0
2nd	1.0(0.5 – 2.0)	0.921
3rd	1.0(0.5 – 2.2)	0.921
Highest	1.2(0.5 – 2.8)	0.693
Kynurenine		0.936
Lowest	1.0
2nd	1.3(0.7 – 2.3)	0.448
3rd	1.1(0.5 – 2.2)	0.792
Highest	1.1(0.5 – 2.6)	0.744
Quinolinic acid		0.270
Lowest	1.0
2nd	0.72(0.39 – 1.31)	0.276
3rd	0.68(0.35 – 1.32)	0.250
Highest	0.61(0.29 – 1.31)	0.207
Tryptophan		0.895
Lowest	1.0
2nd	1.0(0.6 – 1.9)	0.882
3rd	1.0(0.5 – 1.9)	0.985
Highest	1.0(0.5 – 2.1)	0.905
Xanthurenic acid		0.718
Lowest	1.0
2nd	0.89(0.45 – 1.78)	0.749
3rd	1.3(0.6 – 2.7)	0.502
Highest	1.1(0.4 – 2.6)	0.870

RR = 1.0 is the reference category.

p values of trend of metabolites in italics

Significant p-value after Benjamini-Hochberg correction with false discovery rate at 0.20 and n=44 in bold

^*Adjusted for ethnicity, smoking status, type of milk feed, caesarean delivery and infant sex