Table V. p-values of paired student’s t-test are demonstrated to test the significance of performance difference for different methods. p-values higher than 0.05 are highlighted in bold face.

	ESUPNet	UNetMF	MMED-S	SegNetRF	CNTCVX	LDAMT	HQNet	CNN3DST	FCN2D3D	EnCNNU	DenseUMT
Areas
ResUNet	<0.001	0.41	<0.001	<0.001	0.042	0.98	<0.001	<0.001	<0.001	0.25	0.0033
ESUPNet		< 0.001	0.10	<0.001	<0.001	< 0.001	<0.001	<0.001	0.07	<0.001	0.0062
UNetMF			<0.001	<0.001	0.20	0.38	<0.001	<0.001	<0.001	0.74	0.028
MMED-S				<0.001	0.03	< 0.001	<0.001	<0.001	<0.001	<0.001	0.22
SegNetRF					<0.001	< 0.001	<0.001	0.0013	<0.001	<0.001	<0.001
CNTCVX						0.034	<0.001	<0.001	<0.001	0.33	0.38
LDAMT							<0.001	<0.001	<0.001	0.22	0.0023
HQNet								<0.001	<0.001	<0.001	<0.001
CNN3DST									<0.001	<0.001	<0.001
FCN2D3D										<0.001	<0.001
EnCNNU											0.057
Dimensions
ResUNet	0.041	< 0.001	<0.001	<0.001	<0.001	0.031	<0.001	<0.001	<0.001	<0.001	<0.001
ESUPNet		< 0.001	<0.001	<0.001	<0.001	0.97	<0.001	<0.001	<0.001	<0.001	<0.001
UNetMF			0.034	0.25	<0.001	< 0.001	<0.001	<0.001	<0.001	<0.001	<0.001
MMED-S				<0.001	<0.001	< 0.001	<0.001	<0.001	<0.001	<0.001	<0.001
SegNetRF					<0.001	< 0.001	<0.001	<0.001	<0.001	<0.001	<0.001
CNTCVX						< 0.001	<0.001	<0.001	0.21	0.036	0.05
LDAMT							<0.001	<0.001	<0.001	<0.001	<0.001
HQNet								<0.001	<0.001	<0.001	<0.001
CNN3DST									<0.001	<0.001	0.0011
FCN2D3D										0.00021	0.44
EnCNNU											<0.001
RWTs
ResUNet	<0.001	< 0.001	0.0092	<0.001	<0.001	0.014	<0.001	0.087	<0.001	0.09	0.17
ESUPNet		0.05	0.0063	<0.001	0.9	< 0.001	<0.001	0.047	0.55	<0.001	<0.001
UNetMF			0.41	<0.001	0.062	< 0.001	<0.001	0.52	0.014	<0.001	<0.001
MMED-S				<0.001	0.0083	< 0.001	<0.001	0.94	0.0014	<0.001	<0.001
SegNetRF					<0.001	< 0.001	<0.001	<0.001	<0.001	<0.001	<0.001
CNTCVX						< 0.001	<0.001	0.055	0.49	<0.001	<0.001
LDAMT							<0.001	<0.001	<0.001	0.55	0.38
HQNet								<0.001	<0.001	<0.001	<0.001
CNN3DST									0.018	0.0038	0.0077
FCN2D3D										<0.001	<0.001
EnCNNU											0.78