Table 2.
Comparison of clinical and biochemical characteristics of patients with a KATP channel mutation diagnosed before six months of age with patients whose diabetes was not diagnosed before 6 months, and the number of each mutation identified within each group. Results are in median, range given in brackets. Differences between groups were calculated using Mann-Whitney U and Chi-squared. Centile birth weights were calculated according to UK growth charts (28) as the majority of patients were of UK white origin.
| Characteristic | Mutation carriers diagnosed with diabetes within 6 months (n=35) | Mutation carriers who did not have diabetes diagnosed within the first 6 months (n= 16) | P -Value |
|---|---|---|---|
| % Males | 51% | 44% | 0.75 |
| Number of probands | 25 | 0 | |
| Age when entering study (years) | 6 (0.8 -43) | 42 (5 - 56) | - |
| Number ever diagnosed with diabetes | 35 | 7 | 1*10-6 |
| Age at diagnosis (weeks) | 4 (0-17) | 1196 (260 - >2496) | 3.7*10-5 |
| Number where diabetes has remitted | 32 | 0 /7 | 3.7*10-10 |
| Age at remission (weeks) | 35 (2-208) | - | - |
| Number where diabetes has relapsed | 7 | - | - |
| Age at relapse (years) | 13 (3 - 25.5) | - | - |
| Birth weight (g) | 2695 (1360-3570) | 2810 (907-3090) | 0.9 |
| Gestation (weeks) | 39 (30-42) | 38 (34-40) | 0.74 |
| Centile birth weight | 18 (<1st -89) | 15 (<1st - 79) | 0.94 |
| KCNJ11Mutations: | |||
| R34C | 1 | 2 | |
| G53R | 2 | 0 | |
| G53S | 2 | 1 | |
| E179A | 1 | 0 | |
| I182V | 1 | 0 | |
| E227K | 4 | 2 | |
| E229K | 5 | 3 | |
| R365H | 1 | 1 | |
| ABCC8 Mutations: | |||
| D209E | 1 | 1 | |
| D212N | 2 | 1 | |
| D212I | 4 | 0 | |
| V324M | 1 | 1 | |
| L451P | 2 | 1 | |
| R826W | 1 | 0 | |
| R1183W | 4 | 2 | |
| R1183Q | 1 | 0 | |
| R1380C | 1 | 0 | |
| R1380H | 1 | 1 |