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. Author manuscript; available in PMC: 2021 Oct 14.
Published in final edited form as: Nat Med. 2021 May 27;27(6):1088–1096. doi: 10.1038/s41591-021-01349-y

Extended Data Figure 1. Differences in body mass index in those sequenced for MC4R LoF mutations and those not sequenced from the rest of ALSPAC.

Extended Data Figure 1

Estimates reflect the mean difference (95% CI) in BMI (kg/m2) comparing those sequenced for MC4R LoF mutations to those not sequenced, obtained from two-sided t-tests (p-values were not corrected for multiple comparisons). ALSPAC = Avon Longitudinal Study of Parents and Children; BMI = body mass index; CI = confidence interval; LoF = loss of function.