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. Author manuscript; available in PMC: 2021 Oct 14.
Published in final edited form as: Nat Med. 2021 May 27;27(6):1088–1096. doi: 10.1038/s41591-021-01349-y

Extended Data Figure 5. Association between MC4R LoF of cAMP accumulation and arterial BP across age in a model adjusting only for sex and a model adjusted for sex and BMI at the same age.

Extended Data Figure 5

Estimates represent the change (mmHg) in SBP or DBP (top and bottom panel, respectively) in carriers (i.e., pLoF or cLoF) vs. non-LoF carriers (i.e., individuals with synonymous, common variations or no LoF mutations and individuals with WT-like and GoF mutations) of MC4R LoF mutations, obtained from linear regression (p-values presented are two-sided and not corrected for multiple comparisons). BMI = body mass index; BP = blood pressure; CI = confidence interval; cLoF = complete loss of function; DBP = diastolic blood pressure; GoF = gain of function; LoF = loss of function; pLoF = partial loss of function; SBP = systolic blood pressure; WT-like = wild-type like.