Fig. 1.
A, Representative whole-cell currents recorded from Xenopus oocytes coexpressing SUR1 and either Kir6.2, Kir6.2-28Δ32 (hom28Δ32), or both Kir6.2 and Kir6.2-28Δ32 (het28Δ32) in response to voltage steps of ± 20 mV from a holding potential of −10 mV. B, Mean steady-state whole-cell KATP currents recorded from oocytes coexpressing SUR1 and either wild-type or mutant Kir6.2, as indicated. Currents were evoked by a voltage step from −10 to −30 mV before (control, white bars) and after (black bars) application of 3 mM azide, and in the presence of 3 mM azide plus 0.5 mM tolbutamide (gray bars). The number of oocytes is indicated below the bars. *, P ≤ 0.05 against control (t test).