Table. Vital status, age at death, and prevalence of outcomes in first-degree relatives, as reported by UK Biobank participants.
| Father (median N=400 687*) | Mother (median N=423 692*) | Siblings (median N=361 816*) | |
|---|---|---|---|
| Age at death, years, mean (SD)† | 70·9 (13·1) | 75·7 (13·3) | NA |
| Still alive | 103 919/450 333 (23·1%) | 180 472/454 999 (39·7%) | NA |
| Alzheimer’s disease or dementia | 19 255/399 793 (4·8%) | 36 548/423 738 (8·6%) | 2094/361 264 (0·6%) |
| Bowel cancer | 23 883/399 920 (6·0%) | 22 028/423 135 (5·2%) | 8920/361 508 (2·5%) |
| Breast cancer | NA | 35 102/423 458 (8·3%) | 16 586/361 809 (4·6%) |
| Chronic bronchitis or emphysema | 46 263/402 389 (11·5%) | 25 314/423 692 (6·0%) | 10 325/361 823 (2·9%) |
| Diabetes | 38 850/400 687 (9·7%) | 40 091/423 892 (9·5%) | 31 073/362 826 (8·6%) |
| Heart disease | 133 320/407 557 (32·7%) | 85 620/426 240 (20·1%) | 37 858/363 542 (10·4%) |
| High blood pressure | 91 242/402 899 (22·6%) | 130 948/426 391 (30·7%) | 77 059/364 661 (21·1%) |
| Lung cancer | 37 443/401 624 (9·3%) | 17 566/423 258 (4·2%) | 8199/361 586 (2·3%) |
| Parkinson’s disease | 10 106/399 089 (2·5%) | 6998/422 464 (1·7%) | 2005/361 199 (0·6%) |
| Prostate cancer | 30 945/399 670 (7·7%) | NA | 5952/361 394 (1·6%) |
| Severe depression | 15 430/399 499 (3·9%) | 28 351/423 217 (6·7%) | 26 368/362 315 (7·3%) |
| Stroke | 62 810/402 616 (15·6%) | 60 880/424 977 (14·3%) | 12 031/361 925 (3·3%) |
Data are % cases unless otherwise stated (numbers of cases and controls for each outcome are presented in appendix 1 table S4). NA=not applicable.
*
Value corresponds to the median number of UK Biobank participants reporting any outcome in fathers, mothers, or siblings (details are provided in appendix 1 table S4).
†
Age at death for fathers of 341 118 UK Biobank participants and mothers of 273 111 UK Biobank participants.