Skip to main content
. 2021 Aug 20;81(21):5438–5450. doi: 10.1158/0008-5472.CAN-21-0613

Figure 1.

Figure 1. A, Chemical structure of eCF506. B, Structure of eCF506 bound to the inactive conformation of the SRC kinase domain (DFG in, C-helix out). Amino acid numbering corresponds to human SRC. C, Superimposed structures of autoinhibited SRC kinase (PDB 2SRC) and co-crystal structures SRC:eCF506 (PDB 7NG7) and SRC:dasatinib (PDB 3G5D). The orientation of the C-helix is highlighted.

A, Chemical structure of eCF506. B, Structure of eCF506 bound to the inactive conformation of the SRC kinase domain (DFG in, C-helix out). Amino acid numbering corresponds to human SRC. C, Superimposed structures of autoinhibited SRC kinase (PDB 2SRC) and co-crystal structures SRC:eCF506 (PDB 7NG7) and SRC:dasatinib (PDB 3G5D). The orientation of the C-helix is highlighted.