Table 1. Metabolic and renal biochemical parameters assessed in-preclinical studies of metabolic surgery for experimental diabetic kidney disease.a .
| Study | Obesity and DKD model | Surgery type | Postoperative follow-up | Body weight | Plasma glucose (mmol/L) | Plasma lipids (mmol/L) | Proteinuria | Glomerular filtration rate | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | ||||
| Zhiqing et al., 2014 [20] | High-fat diet (40% fat) plus low-dose streptozotocin (35mg/kg) in Sprague Dawley rats | DJB | 8 weeks | 310±10g | 340±10g | 25±3 mmol/L (R) | 6±3 mmol/L (R) | N/A N/A |
1.5 ± 0.2 (TC) 1.2 (0.7 (TG) |
20±4 mg/24h (UAER) | 30±7 mg/24h (UAER) | 9±2 mL/g/day (CrCl) | 8±3 mL/g/day (CrCl) |
| Wang et al., 2016 [22] | High-fat diet (40% fat) plus low-dose streptozotocin (30mg/kg) in Sprague Dawley rats | RYEJ | 8 weeks | 375±20g | 300±20g | 18±2 mmol/L (F) | 7±1 mmol/L (F) | N/A | N/A | 15±2 mg/24h (UAER) | 20±3 mg/24h (UAER) | 10±2 mL/g/day CrCl) | 8±2 mL/g/day (CrCl) |
| Neff et al., 2017 [17] | Zucker diabetic fatty rat (fa/fa) | RYGB | 13 weeks | 430±10g | 390±10g | N/A, clamped <15mmol/L using insulin | N/A | N/A | 1.6±0.3g/mmol (UPCR) | 0.4±0.3g/mmol (UPCR) | N/A | N/A | |
| Wu et al., 2018 [21] | High-fat diet (40% fat) plus low-dose streptozotocin (35mg/kg) in Sprague Dawley rats | DJB | 8 weeks | 360±10g | 390±10g | 3000±200 (AUCOGTT) | 1500±200 (AUCOGTT) | N/A | N/A | 19±4 mg/24h (UAER) | 20±4 mg/24h (UAER) | 9±2 mL/g/day (CrCl) | 8±1 mL/g/day (CrCl) |
| Canney et al., 2019 [18] | Zucker diabetic fatty rat (fa/fa) | RYGB | 7 weeks | 387±5g | 285±7g | 30±0.9 mmol/L (R) | 8.3±1 mmol/L (R) | N/A | N/A | 650±1000 mg/g (UACR) | 68±21 mg/g (UACR) | N/A | N/A |
| Xiong et al., 2020 [23] | High-fat diet (40% fat) plus low-dose streptozotocin (35mg/kg) in Wistar rats | SG | 12 weeksb | 410±10g | 380±20g | 15±1 mmol/L (F) | 8.5±2 mmol/L (F) | N/A | N/A | 5±1 mg/g (UACR) | 4±1 mg/g (UACR) | N/A | N/A |
| Nair et al., 2020 [19] | Zucker diabetic fatty rat (fa/fa) | RYGB | 8 weeks | 390±10g | 324±24g | 25±2 mmol/L (F) | 7.2±2.7 mmol/L (F) | N/A N/A |
2.5 ±0.2 (TC) 4.2 [IQR 5.2-6] (TG) | 239.4±245.4 μg/mg (UACR) | 30.7±25.8 μg/mg (UACR) | N/A | N/A |
a
Where raw numerical data not reported, approximate values estimated from figures in manuscript.
b
This study evaluated outcomes at 3 timepoints (4, 8, and 12 weeks); data from the final timepoint (12 weeks) is presented.
AUCOGTT, glucose area under the curve derived from oral glucose tolerance test; CrCl, 24-hour urinary creatinine clearance; DJB, duodeno-jejunal bypass; F, fasting; IQR, interquartile range; N/A, not assessed; R, random; RYEJ, Roux-en-Y esophagojejunostomy; RYGB, Roux-en-Y gastric bypass surgery; SG, sleeve gastrectomy; TC, total cholesterol; TG, triglycerides; UACR, urinary albumin-to-creatinine ratio; UAER, urinary albumin excretion rate; UPCR, urine protein-to-creatinine ratio.