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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2021 Aug 14;111(5):1250–1261. doi: 10.1016/j.ijrobp.2021.08.004

Figure 2.

Figure 2

Intestinal normal tissue response after conventional dose rate irradiation (CONV IR) vs. ultra-high dose rate irradiation (FLASH IR). Radiation dose response curve of small intestinal crypts for mice (C3H mice, female); A) aged 9-10 weeks (n = 6 for each group), B) aged 30-31 weeks (n = 4 for 0 Gy and 12.5 Gy FLASH IR, n = 6 for 5 Gy, n = 3 for the other groups). The individual data points were fitted with a sigmoidal dose response curve using the nonlinear regression analysis in GraphPad Prism. Error bars show standard error of the mean (SEM). * p < 0.05, ** p < 0.01. C) Representative H&E images of intestinal Swiss rolls from each treatment group. Scale bar = 200 μm.