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. Author manuscript; available in PMC: 2021 Nov 22.
Published in final edited form as: DNA Repair (Amst). 2021 Jul 14;106:103179. doi: 10.1016/j.dnarep.2021.103179

Fig. 2. Model of 53BP1 condensation at sites of DNA damage.

Fig. 2

At the spatial and temporal scales relevant for the DNA damage response, 53BP1 condensation may be favored both kinetically, through enzymatically-controlled deposition of histone marks, and thermodynamically, through self-assembly of 53BP1 into mature oligomers to form a denser 53BP1 compartment.