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The propensity of 53BP1 to self-interact may play a role for the formation of 53BP1 nanodomains, for the assembly of multiple nanodomains into bigger microdomains, and for the fusion of microdomains into large DNA repair centers. The multi-layered organization of these domains enables tuning of DNA end resection and repair pathway choice according to replication and chromatin status, cell cycle position, and lesion complexity.
