Table 3.

Multivariable associations between risk of allergen skin prick test positivity (SPT+) to any and to mite allergens during first 8 years of life and infection intensities with A. lumbricoides and T. trichiura.

STH parasite	SPT+ to any allergen			SPT+ to mite
	OR	95% CI	p-value	OR	95% CI	p-value
A. lumbricoides
Uninfected	1			1
Light	0.87	0.67–1.14	0.319	0.80	0.58–1.10	0.176
Moderate/heavy	0.78	0.51–1.17	0.229	0.36	0.18–0.72	0.004
T. trichiura
Uninfected	1			1
Light	0.90	0.70–1.16	0.402	0.78	0.57–1.07	0.129
Moderate/heavy	1.07	0.61–1.91	0.807	0.38	0.13–1.11	0.077

Population average multivariable models were fitted to the binary longitudinal outcomes defined by presence/absence of SPT+ in children followed up between 2 and 8 years of age. Estimates were controlled for age and age². Age effects were non-linear (p < 0.001): STH, soil-transmitted helminth; tv, time-varying covariates. Models were fit using generalized estimating equations under missing completely at random assumption for unobserved data points, and adjusted for age, maternal allergic symptoms and polysensitization, area of residence, birth order, crowding (tv), agriculture exposure (tv), and anthelmintic treatment (tv), according to outcome as shown for multivariable models in Table 2. OR, odds ratio; 95% CI, 95% confidence intervals. Infection intensity categories were: A. lumbricoides (light−1–4,999; moderate−5,000–49,999; and heavy—≥50,000 epg) and T. trichiura (light−1–999; moderate−1000–9,999; and heavy—≥10,000 epg). P < 0.05 are shown in bold.