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. Author manuscript; available in PMC: 2021 Dec 21.
Published in final edited form as: Nat Hum Behav. 2021 Jul 1;5(12):1717–1730. doi: 10.1038/s41562-021-01135-3

Figure 5. Gene prioritization of age at first sex (AFS) and age at first birth (AFB).

Figure 5

Information for 99 genes prioritized in loci identified by GWAS for age at first sex and/or age at first birth that are located within 1 million bp of lead SNPs and are expressed at the protein level in brain, glands and/or reproductive organs. Transitions in colour from blue to orange highlight whether the gene in the next row is still within the same locus or not. Numbers before the genes show the chr. Panels are separated by vertical grey lines. The first panel (left) indicates if the locus was identified as being associated at genome-wide significance with age at first sex (AFS) and/or age at first birth (AFB). The second panel shows which bioinformatic approaches highlighted the gene as a candidate. The third panel shows – from left to right - the cell types in brain, glands, female reproductive organs, and male reproductive organs in which the genes are expressed at a low, moderate or high level (small, medium and large circles), based on data from the Human Protein Atlas. The fourth panel shows gene functions as extracted from Entrez, Uniprot and GeneCards. The fifth panel indicates which phenotypes were observed in mutant mice, as reported by the Mouse Genome Informatics (MGI) database.