TABLE 5.

Participants’ Problems With Calculations Identified During Round 1 and the Consequent Guide Revisions Made Before Round 2

Direct Question	Round 1 Problem	Guide Revision Before Round 2
Q5: Suppose you are preparing a dose of 600 mg of bathicillin. What size infusion bag should be used?	Three participants did not find the voriconazole concentration range required to answer this question. Four further participants could not use this information to calculate the correct answer	Provide suggested dilution volumes instead of a concentration range, thus removing the need for a calculation
Q7: Imagine you are making an infusion of 270 mg of bathicillin. How much reconstituted solution should you add to the infusion bag?	Seven participants did not account for the displacement volume of voriconazole	Use bold text and bullet points to emphasize the concentration of the reconstituted solution.
Q9: Imagine you were giving a dose of 420 mg of bathicillin to a patient weighing 70 kg. What’s the shortest time the infusion should last?	Four participants could not perform the calculation needed to answer this question	Provide an equation and table to calculate the infusion rate
Q11: Suppose you were programming an infusion pump for a continuous infusion of unimycin at a rate of 700 μg/kg per hour for a patient weighing 65 kg. What infusion rate do you require in milliliter per hour?	Participants stated that weight-based infusion rate calculations were not relevant to their practice, as weight-based calculations were performed by prescribers	Move this information to a new “example dose calculation” subsection, and add an equation and example calculation linking infusion rate, prescribed dose and concentration