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. Author manuscript; available in PMC: 2022 Jan 3.
Published in final edited form as: Sci Signal. 2019 Aug 6;12(593):eaav9150. doi: 10.1126/scisignal.aav9150

Fig. 2. PKD3 promotes insulin resistance and glucose intolerance.

Fig. 2

A Body weight evolution of control and pKD3 liverΔ/Δ mice fed a HFD for 24 weeks.

B Organ weight of control and pKD3 liverΔ/Δ mice fed a HFD for 24 weeks.

C-E Glucose (2 g/kg BW) (C) and insulin (1.5 U/kg BW) (D) tolerance tests and serum insulin levels (E) in pKD3 liverΔ/Δ and control mice after HFD feeding for 16, 18 and 24 weeks, respectively.

F, G Western blot analysis for the indicated proteins in the livers of mice of the indicated genotypes given insulin (8 U/kg body weight) for 15 min after 24 weeks of HFD feeding and (F) and corresponding densitometric quantification (G) (n=5 mice/group).

Data information: In (A-E), n=8 mice (WT) and n=15 mice (KO) were used and in (A-E, G) data are presented as mean ± SEM. *P>0.05, **P>0.01, ***P>0.001 (unpaired two-tailed Student’s t-test (B, E), one way ANOVA with post hoc Tukey’s test (G), or two way ANOVA with post hoc Tukey’s test (A, C, D)).