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. Author manuscript; available in PMC: 2022 Jan 3.
Published in final edited form as: Sci Signal. 2019 Aug 6;12(593):eaav9150. doi: 10.1126/scisignal.aav9150

Fig. 7. Liver-specific expression of a constitutively active PKD3 promotes insulin resistance.

Fig. 7

A, B Glucose (2 g/kg BW) (A) and insulin (1 U/kg BW) (B) tolerance test in TgPKD3cahver and control mice fed a ND for 12 and 10 weeks, respectively. (n=11 mice (Control) and n=13 mice (Tg)).

C-E After overnight fast, blood glucose (C) and insulin (D) were measured and used to determine HOMA-IR (E) in mice of the indicated genotypes (n=11 mice (Control) and n=13 mice (Tg)).

F, G Western blot analysis of the indicated proteins from livers of mice of the indicated genotypes that were fasted overnight and refed 4 h before analysis (F) and corresponding densitometric quantification (G) (n=3 mice/group).

H Summary of PKD3 signaling in liver.

Data information: In (A-E and G), data are presented as mean ± SEM. *P>0.05, **P>0.01, ***P>0.001 (unpaired two-tailed Student’s t-test (C-E, G) or two way ANOVA with post hoc Tukey’s test (A, B)).