Table 1. Summary of error rate and predictive values in terms of number of treatments within each category (recommended/non-recommended vs truly effective/truly ineffective).
Recommended treatments | Non-recommended treatments | |
---|---|---|
Non-effective treatments | A | B |
Effective treatments | C | D |
Family-wise error rate | P(A > 0) | |
FDR | E(A/[A + C])a | |
PPV | C/(A + C) | |
NPV | B/(B + D) |
Abbreviations: FDR, false-discovery rate; NPV, negative predictive value; PPV, positive predictive value.
The FDR is defined as 0 when the denominator A + C is 0.