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. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: Nature. 2021 Jan 20;591(7850):420–425. doi: 10.1038/s41586-020-03166-8

Figure 4. Striatal mirroring of cortical activity is cell-type specific.

Figure 4

a, Spike waveforms and autocorrelelograms for striatal medium spiny neurons (MSNs), fast spiking interneurons (FSIs), and tonically active neurons (TANs) (mean ± s.d. across cells). b, Heatmaps showing firing rates of individual cells of each class aligned to contralateral stimuli (red lines), contralaterally-orienting movements (purple lines), and rewards (blue lines), averaged across trials with reaction times < 500 ms, max-normalized, and sorted by time of maximum activity using half of the trials and plotting the other half of trials. Rows correspond to striatal domains: DMS, DCS, and DLS, columns to cell types. c, Activity as in (b) averaged across neurons of each cell type and domain (black). For reference, each row reports the cortical activity within a region of cortex associated with each domain (green), providing a close match with MSN and FSN activity but not with TAN activity. d, Correlations of activity in individual neurons (rows in b) with the average activity of each cell type in the same striatal domain (black curves in c), or with activity of the topographically associated cortical ROI (green curves in c), from non-overlapping sessions to account for interneuron sparsity (mean ± s.e. across sessions). MSNs and FSIs were equally correlated with themselves as with each other (shuffling MSN/FSI labels within sessions, MSN: p = 0.47, FSI: p = 0.99 across 77 sessions), or with cortical activity (2-way ANOVA on firing rate and type, type MSN p = 0.94, FSI p = 0.88 across 77 sessions). TANS were correlated with themselves and equally uncorrelated to MSNs, FSIs, and cortical activity (2-way ANOVA on firing rate and type, TAN vs. MSN p = 7.5*10-48, TAN vs. FSI p = 2.0*10-6, TAN vs. MSN, FSI, and cortex p = 0.68 across 77 sessions).