Table 3. Cardiopulmonary exercise testing (CPET) variables before and after neoadjuvant chemotherapy (NAC) and chemoradiotherapy (CRT).
| Pre-NAC/CRT
(n=109) |
Post-CRT/NAC
(n=109) |
Difference (95% CI) | P-value | |
|---|---|---|---|---|
| VO 2 at AT (ml.min -1) | 0.91 (0.27) | 0.8 (0.26) | -0.11 (-0.16 to -0.07) | <0.0001 |
| VO 2 at AT (ml.kg -1.min -1) | 11.72 (2.97) | 10.47 (3.18) | -1.25 (-1.80 to -0.69) | <0.0001 |
| VO 2 at Peak (ml.min -1) | 1.62 (0.51) | 1.37 (0.49) | -0.25 (-0.32 to -0.18) | <0.0001 |
| VO 2 at Peak (ml.kg -1.min -1) | 20.81 (5.93) | 17.79 (5.58) | -3.02 (-3.85 to -2.20) | <0.0001 |
| WR at AT (W) | 62.9 (30.76) | 53.19 (28.35) | -9.71 (-14.37 to -5.04) | 0.0001 |
| WR at Peak (W) | 134.8 (49.6) | 117.39 (48.29) | -17.39 (-24.08 to -10.69) | <0.0001 |
| V E/VCO 2 at AT | 35.11 (4.50) | 36.96 (5.93) | 1.85 (0.94 to 2.76) | <0.0001 |
| V E/VCO 2 at Peak | 35.89 (4.43) | 37.61 (5.73) | 1.73 (0.96 to 2.49) | <0.0001 |
| V E/VO 2 at AT | 29.49 (4.44) | 32.65 (6.46) | 3.15 (2.10 to 4.21) | <0.0001 |
| V E/VO 2 at Peak | 41.86 (7.40) | 45.73 (10.14) | 3.87 (2.50 to 5.25) | <0.0001 |
| PETCO 2 at AT | 37.52 (3.20) | 35.95 (5.07) | -1.57 (-2.48 to -0.66) | 0.0009 |
| PETCO 2 at Peak | 35.39 (3.64) | 34.18 (4.17) | -1.20 (-1.77 to -0.63) | 0.0001 |
| VO 2/HR at AT (ml.beat -1) | 8.84 (2.68) | 7.70 (2.31) | -1.13 (-1.48 to -0.79) | <0.0001 |
| VO 2/HR at Peak (ml.beat -1) | 11.47 (3.27) | 9.98 (3.12) | -1.49 (-1.87 to -1.11) | <0.0001 |
Data are mean (SD) unless otherwise stated. Statistical significance was taken as <0.05 and highlighted in bold.
Abbreviations: NAC (neoadjuvant chemotherapy), CRT (neoadjuvant chemoradiotherapy), VO 2 at AT (oxygen uptake at anaerobic threshold), VO 2 at Peak (oxygen uptake at peak exercise), WR at AT (work rate at anaerobic threshold), WR at Peak (work rate at peak exercise), V E/VCO 2 at AT (ventilatory equivalent for carbon dioxide at the anaerobic threshold), V E/VCO 2 at Peak (ventilatory equivalent for carbon dioxide at peak exercise), V E/VO 2 at AT (ventilatory equivalent for oxygen at the anaerobic threshold), V E/VO 2 at Peak (ventilatory equivalent for oxygen at peak exercise), PETCO 2 at AT (end tidal carbon dioxide at the anaerobic threshold), PETCO 2 at Peak (end tidal carbon dioxide at peak exercise), VO 2/HR at AT (oxygen pulse at the anaerobic threshold), VO 2/HR at Peak (oxygen pulse at peak exercise