Table 4. Surgery and Histopathological Outcomes.
| Pre-and post-
NAC/CRT data and surgery (n=100) |
Pre-NAC/CRT
data and surgery (n=8) |
P-value | |
|---|---|---|---|
| Operation | |||
| Esophagectomy | 71 (71%) | 4 (50.0%) | 0.324 |
| Gastrectomy | 23 (23%) | 3 (37.5%) | |
| Palliative | 6 (6%) | 1 (12.5%) | |
| Operation type | |||
| Unknown | 0 (0%) | 0 (0%) | 0.605 |
| Open | 35 (35%) | 3 (37.5%) | |
| Laparoscopic | 58 (58%) | 4 (50%) | |
| Laparoscopic converted to open | 1 (1%) | 0 (0%) | |
| Palliative resection | 6 (6%) | 1 (12.5%) | |
| Pathology staging | |||
| Tumour stage (T-stage) a* | |||
| 0 | 16 (15.0%) | 0 (0%) | 0.459 |
| 1a +1b | 11 (11.7%) | 1 (14.3%) | |
| 2 +2a | 14 (14.9%) | 2 (28.6%) | |
| 3 | 47 (50.0%) | 3 (42.9%) | |
| 4 | 6 (6.4%) | 1 (14.3%) | |
| Nodal stage (N-Stage) a* | |||
| 0 | 43 (45.7%) | 4 (57.1%) | 1 |
| 1 | 25 (26.6%) | 2 (28.6%) | |
| 2 | 18 (19.2%) | 1 (14.3%) | |
| 3 | 5 (5.3%) | 0 (0%) | |
| 3a | 3 (3.2%) | 0 (0%) | |
| Resection (R0/R1) a | |||
| 0 | 75 (79.8%) | 6 (85.7%) | 1 |
| 1 | 19 (20.2%) | 1 (14.3%) | |
| Tumour Regression Grade b | |||
| 1 | 15 (16.0%) | 0 (0%) | 0.579 |
| 2 | 10 (10.6%) | 1 (16.7%) | |
| 3 | 16 (17.0%) | 2 (33.3%) | |
| 4 | 23 (24.5%) | 2 (33.3%) | |
| 5 | 30 (31.9%) | 1 (16.7%) | |
| EMVI (yes) a | 28 (29.8%) | 1 (14.3%) | 0.670 |
| Differentiation c | |||
| Moderate | 35 (36.8%) | 2 (28.6%) | 0.695 |
| None | 13 (13.7%) | 0 (0%) | |
| Poor | 42 (44.2%) | 5 (71.4%) | |
| Well | 5 (5.3%) | 0 (0%) | |
Data are n (%) unless otherwise stated. Statistical significance was taken as <0.05 and highlighted in bold.
Abbreviations: NAC (neoadjuvant chemotherapy), CRT (neoadjuvant chemoradiotherapy. * T-stage and N-stage classified according to TNM v7. a n=101, b n=100, c n=102. $ Tumor Regression Grade (TRG) was based on definitions outlined by the Mandard score. EMVI – Extra mural venous invasion. RO – complete resection with no tumor within 1mm of the resection margin.