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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Nat Metab. 2022 Jan 27;4(1):123–140. doi: 10.1038/s42255-021-00514-4

Figure 8. Schematic representation of oxPPP function in EC.

Figure 8

a, During vascular development blood flow acts on EC forming DA to promote glucose utilization through the oxidative branch of PPP (oxidative PPP: oxPPP). PPP metabolism produces R5P which is important for EC viability and elastin synthesis. Elastin is then deposited into ECM and drives vMC recruitment and/or differentiation around the DA of developing animals. In oxPPP blockade conditions, this mechanism is impaired leading to a vascular phenotype characterized by a “naked” and immature DA.