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. Author manuscript; available in PMC: 2022 Aug 8.
Published in final edited form as: Circulation. 2022 Feb 7;145(6):416–423. doi: 10.1161/CIRCULATIONAHA.121.056015

Table 3. Change in blood pressure following acetaminophen and placebo: per protocol analysis.

N=90 Acetaminophen Baseline Acetaminophen Day 14 Mean change in baseline to day 14 (acetaminophen) Placebo Baseline Placebo Day 14 Mean change in baseline to day 14 (placebo) Estimate (95% CI) of difference in change from mixed model p-value
Daytime systolic BP
(mmHg) 		133.1 ± 10.6 136.7 ± 10.2 3.6 ± 6.9 134.1 ± 10.5 132.9 ± 10.2 -1.2 ± 7.6 4.5
(2.5 to 6.5)		 <0.0001
24-hr systolic BP
(mmHg) 		126.7 ± 9.9 130.3 ± 9.9 3.6 ± 6.6 127.5 ± 9.7 126.7 ± 9.3 -0.9 ± 7.0 4.2
(2.3 to 6.1)		 <0.0001
Daytime diastolic BP
(mmHg) 		80.8 ± 7.8 81.8 ± 7.7 1.0 ± 3.9 81.4 ± 7.7 80.8 ± 7.9 -0.5 ± 4.4 1.5
(0.3 to 2.7)		 0.015
24-hr diastolic BP
(mmHg) 		76.5 ± 7.5 77.5 ± 7.4 1.0 ± 4.0 77.0 ± 7.0 76.5 ± 7.1 -0.4 ± 4.1 1.4
(0.2 to 2.5)		 0.021
Clinic systolic BP
(mmHg) 		137.4 ± 11.0 140.1 ± 11.8 2.7 ± 10.2 137.0 ± 10.3 135.5 ± 10.4 -1.5 ± 9.0 4.4
(2.1 to 6.7)		 0.0002
Clinic diastolic BP
(mmHg) 		85.6 ± 8.6 85.9 ± 8.9 0.3 ± 6.3 85.3 ± 8.4 84.3 ± 8.6 -1.0 ± 6.2 1.5
(-0.1 to 3.0)		 0.059

Per protocol analysis included all patients with appropriately detectable acetaminophen during the study. P values were derived from a mixed model with treatment, period, and baseline blood pressure as fixed effects and participant as a random effect. Data are shown as mean ± SD. Estimate (95% CI) of difference in change from the mixed model is presented as least square means.