Figure 1.

Associations of circulating metabolites with risk of incident T2D (n = 882), adjusted for fasting time. Adjusted for age (numeric), sex, study area (10 areas), education (6 categories), fasting time (numeric), smoking (ever regular vs. other), alcohol drinking (ever regular vs. other), physical activity (metabolic equivalent of task hours/day, numeric), dietary factors (frequency of consumption of meat, fish, fresh fruit, dairy products; 4 times/week or more vs. other), family history of diabetes (any first-degree relative vs. none), BMI (numeric), and waist circumference (numeric). Squares represent the HR per 1-SD higher metabolite. Horizontal lines represent the corresponding 95% CI. Fatty acid ratios represent ratios of individual to total fatty acids. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 after adjustment for multiple testing using Benjamini-Hochberg correction.