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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Nat Biotechnol. 2021 Sep 27;40(2):198–208. doi: 10.1038/s41587-021-01019-x

Fig. 2. Long-term biointegration and photostimulation in ecological environments.

Fig. 2

a, 3D rendering of the vertebra T13-L3 and micro-LED array reconstructed from high-resolution CT scans

b, MRI of a spinal cord without and with an implanted micro-LED array. The bar graph reports the mean circularity of the spinal cord (n=4-6 mice, two-sided unpaired t-test, p = 0.67, mean±s.e.m.).

c, Chronophotography of a mouse walking freely and with precise paw placement along a horizontal ladder, despite the implanted micro-LED array and wearable platform. The bar plot reports quantification of the percentage of foot falls (n=6-8 mice, two-sided unpaired t-test, p = 0.57, mean±s.e.m.).

d, Chronophotography of mice performing classical behavioural paradigms in ecological environments while receiving continuous photostimulation of the lumbar spinal cord. The paradigms include climbing up a rope, swimming in a large tank of water, and narrow beam walking.