Table 3. Multivariable analysis of the relation between quartiles of GIP/GLP-1 and IMTmeanCCA/IMTmaxBulb.
Quartiles of fasting GIP | Quartiles of postchallenge GIP* | |||
---|---|---|---|---|
β (SE) | P | β (SE) | P | |
Associations between quartiles of GIP and IMTmeanCCA | ||||
Q1 | Referent | — | Referent | — |
Q2 | 0.003 (0.010) | 0.758 | 0.020 (0.011) | 0.059 |
Q3 | 0.013 (0.011) | 0.233 | 0.012 (0.011) | 0.260 |
Q4 | 0.023 (0.011) | 0.032 | 0.015 (0.011) | 0.180 |
P trend | 0.008 (0.003) | 0.021 | 0.004 (0.004) | 0.305 |
Associations between quartiles of GIP and IMTmaxBulb | ||||
Q1 | Referent | — | Referent | — |
Q2 | 0.023 (0.018) | 0.202 | −0.010 (0.019) | 0.599 |
Q3 | 0.016 (0.018) | 0.388 | −0.016 (0.020) | 0.412 |
Q4 | 0.035 (0.019) | 0.065 | −0.008 (0.020) | 0.683 |
P trend | 0.010 (0.006) | 0.105 | 0.002 (0.006) | 0.761 |
Associations between quartiles of GLP-1 and IMTmeanCCA | ||||
Q1 | Referent | — | Referent | — |
Q2 | 0.002 (0.011) | 0.828 | −0.002 (0.011) | 0.878 |
Q3 | −0.001 (0.011) | 0.898 | −0.005 (0.011) | 0.639 |
Q4 | −0.007 (0.011) | 0.541 | −0.018 (0.011) | 0.100 |
P trend | −0.003 (0.004) | 0.450 | −0.006 (0.006) | 0.108 |
Associations between quartiles of GLP-1 and IMTmaxBulb | ||||
Q1 | Referent | — | Referent | — |
Q2 | −0.031 (0.019) | 0.115 | −0.016 (0.020) | 0.430 |
Q3 | −0.032 (0.019) | 0.103 | −0.025 (0.019) | 0.200 |
Q4 | −0.038 (0.019) | 0.047 | −0.041 (0.020) | 0.044 |
P trend | −0.007 (0.006) | 0.222 | −0.013 (0.006) | 0.042 |
Data are unstandardized β-coefficients (1-SD increase of incretins per mm IMTmeanCCA or IMTmaxBulb) (β) and SEs. Q1, quartile with lowest values; Q4, quartile with highest values. Analyses of fasting incretins are adjusted for age, sex, BMI, SBP, smoking status, diabetes status, FPG, fasting insulin, HDL, triglycerides, AHT, and lipid-lowering treatment (model 2a). Analyses between postchallenge GIP and IMTmeanCCA are adjusted for age, sex, BMI, SBP, smoking status, diabetes status, postchallenge plasma glucose, postchallenge insulin, HDL, triglycerides, AHT, and lipid-lowering treatment (model 2b).
2 h postchallenge (at 120 min).