Table 4. Hazard ratio for incident coronary artery disease (CAD) by soluble Caspase-3 (sCaspase-3).

	T1	sCaspase-3 (T1/T2/T3)	T3	HR per 1 unit (95% CI)	P
HR (95% CI) model 1	1	1.0 (CI 0.9–1.3)	1.4 (1.1–1.7)	1.17 (1.08–1.27)	0.0001
HR (95% CI) model 2	1	1.0 (CI 0.8–1.2)	1.3 (CI 1.0–1.5)	1.13 (1.04–1.22)	0.004
HR (95% CI) model 3	1	1.0 (CI 0.8–1.2)	1.2 (CI 1.0–1.4)	1.09 (1.003–1.18)	0.04

Model 1—unadjusted. Model 2—adjusted for sex and age. Model 3—adjusted for cardiovascular risk factors according to Framingham (smoking, diabetes, age, sex, total cholesterol, high-density lipoproteins, low-density lipoproteins, diabetes and hypertension) and body mass index. HR, hazard ratio. CI, confidence interval. P-values obtained from linear regression per 1-unit increment of sCaspase-3. N for tertiles 1 and III = 1514 and N for tertile II= 1513 patients.