Figure 5.
Comparison of simulated cellular active stress and intracellular calcium concentration. The blue lines represent the median nodal traces obtained from the simulations that were produced by the 3D model of human left ventricular EM in the first step (Sim1). The red lines represent the traces that were produced by the 0D model of cellular EM in the second step of the active mechanics personalisation approach (Sim2). (a) Cellular active stress traces (solid line represents a target for the personalisation), (b) intracellular calcium concentration traces (dashed line does not represent a target for the personalisation).