Table 1.
HER2 status as a predictor of recurrence: categorized (negative, equivocal, positive) and binary (negative, positive).
| Reference IHC 0, 1+ | Reference IHC 0, 1+, 2+ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||
| Endpoint | Events | HER2 | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
| IBE | 147a | IHC 2+ | 2.77 (1.70–4.54) | <0.0001 | 2.76 (1.63–4.66) | 0.0001 | — | — | — | — |
| IHC 3+ | 2.90 (2.02–4.17) | <0.0001 | 2.46 (1.64–3.68) | <0.0001 | 2.27 (1.64–3.14) | <0.0001 | 1.92 (1.33–2.76) | 0.0004 | ||
| I-IBE | 54 | IHC 2+ | 2.08 (0.97–4.47) | 0.061 | 1.99 (0.88–4.52) | 0.10 | — | — | — | — |
| IHC 3+ | 1.63 (0.91–2.92) | 0.10 | 1.40 (0.73–2.70) | 0.31 | 1.40 (0.81–2.42) | 0.23 | 1.21 (0.65–2.23) | 0.55 | ||
| DCIS-IBE | 91 | IHC 2+ | 3.49 (1.82–6.69) | 0.0002 | 3.52 (1.77–6.99) | 0.0003 | — | — | — | — |
| IHC 3+ | 4.03 (2.47–6.58) | <0.0001 | 3.28 (1.91–5.61) | <0.0001 | 2.90 (1.91–4.40) | <0.0001 | 2.34 (1.47–3.74) | 0.0003 | ||
aRecurrence type not known in two cases. Multivariate analyses are in a smaller number of samples (n = 612) due to non-available clinicopathological data in some samples.