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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: Dev Psychopathol. 2017 Jun 9;30(2):383–397. doi: 10.1017/S095457941700092X

Figure 1. Methylomic variation at birth prospectively associated with early-onset vs low conduct problems in childhood.

Figure 1

Epigenome-wide associations between DNA methylation at birth and early-onset vs low conduct problems (CP), including Q-Q plot (A), Manhattan plot (B) and scatterplots of the top 3 differentially methylated sites with genic annotations (C). Significantly enriched biological processes at birth are shown in (D), based on gene ontology (GO) analysis of genes annotated to probes that associate with early-onset vs low CP (p < 0.001). Circles represent GO terms that survive FDR-correction and contain at least two genes. The X axis represents -log(10) p-values. The opacity of the circles indicates level of significance (darker = more significant). The size of the circles indicates the percentage of genes in our results for a given pathway compared to the total number of genes in the same pathway (i.e. larger size = larger %).