Table 1. DNA methylation sites at birth that differentiate early-onset vs low CP children (genome-wide significance; q<0.05).
| Probe | Gene | Chr | Genomic location | Position | p-value | q-value (FDR) | Direction | Early-onset CP Mean | Low CP Mean | % Diff | Cohen's d |
|---|---|---|---|---|---|---|---|---|---|---|---|
| cg12628061 | -- | 1 | -- | 56453730 | 2.47E-09 | 1.00E-03 | ↓ | 0.77 | 0.81 | 4% | 0.84 |
| cg02131674 | -- | 5 | -- | 17341065 | 1.64E-08 | 3.00E-03 | ↓ | 0.77 | 0.81 | 4% | 0.78 |
| cg15384400 | -- | 4 | -- | 36257279 | 5.09E-08 | 7.00E-03 | ↑ | 0.26 | 0.21 | 5% | 0.79 |
| cg07128473 | -- | 8 | -- | 116891579 | 1.00E-07 | 0.01 | ↓ | 0.83 | 0.86 | 3% | 0.76 |
| cg02503763 | MGLL | 3 | TSS1500 | 127542386 | 1.23E-07 | 0.01 | ↓ | 0.38 | 0.46 | 8% | 0.73 |
| cg21579239 | TTBK2 | 15 | 5'UTR | 43211292 | 1.40E-07 | 0.01 | ↓ | 0.74 | 0.78 | 4% | 0.73 |
| cg16006965 | GCET2 | 3 | TSS1500 | 111852325 | 7.85E-07 | 0.04 | ↓ | 0.53 | 0.6 | 7% | 0.66 |
a
Arrows represent the direction of methylation differences, where ↑ indicates higher methylation levels in early-onset vs low CP children, while ↓ indicates lower methylation levels in early-onset vs low CP children. Cohen’s d: .20 is a small effect size, .50 is a medium effect size, .80 is a large effect size.