Table 2. Candidate gene follow-up: Loci that differentiate between early-onset and low CP children (gene-level Bonferroni correction).
| Probe | Chr | Genomic Location | Position | p-value | q-value (genome-wide) | Bonferroni (gene-level) | Direction | Early-onset CP Mean | Low CP Mean | % Diff | Cohen's d |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BDNF | |||||||||||
| cg01225698 | 11 | Body; TSS1500 | 27742355 | 3.44E-04 | 0.30 | Significant | ↑ | 0.16 | 0.15 | 1% | 0.47 |
| cg18354203 | 11 | Body; 5'UTR | 27696004 | 4.97E-04 | 0.33 | Significant | ↓ | 0.72 | 0.75 | 3% | 0.49 |
| FKBP5 | |||||||||||
| cg07061368 | 6 | 5'UTR | 35631736 | 9.96E-04 | 0.37 | Significant | ↓ | 0.81 | 0.83 | 2% | 0.44 |
| MAOA | |||||||||||
| cg05443523 | X | TSS200 | 43515213 | 1.17E-03 | 0.38 | Significant | ↑ | 0.36 | 0.33 | 3% | 0.44 |
N.b. Arrows represent the direction of methylation differences, where ↑ indicates higher methylation levels in early-onset vs low CP children, while ↓ indicates lower methylation levels in early-onset vs low CP children. Cohen’s d: .20 is a small effect size, .50 is a medium effect size, .80 is a large effect size.