Table 3. Associations between prenatal environmental exposures and loci that are differentially methylated in early-onset vs low CP children.
| Prenatal environment | ||||||||
|---|---|---|---|---|---|---|---|---|
| Healthy diet | Unhealthy diet | Maternal smoking | Maternal alcohol use | Life events | Contextual risks | Parental risks | Interpersonal risks | |
| Genome-wide analyses | ||||||||
| cg12628061 | 0.09 | -0.06 | -0.16 (p = 0.01) a | 0.17 (p = 0.01) | 0.09 | 0.02 | -0.09 | 0.07 |
| cg02131674 | 0.09 | -0.07 | -0.10 | 0.10 | 0.10 | 0.05 | -0.09 | 0.04 |
| cg15384400 | -0.07 | 0.07 | 0.09 | 0.00 | -0.05 | -0.01 | 0.11 | 0.05 |
| cg07128473 | 0.14 (p = 0.03) a | -0.08 | -0.10 | 0.12 | 0.05 | 0.05 | -0.07 | 0.06 |
| cg02503763 (MGLL) | 0.03 | -0.01 | -0.14 (p = 0.02) | 0.13 (p = 0.03) a | -0.05 | -0.04 | -0.08 | -0.02 |
| cg21579239 (TTBK2) | 0.08 | -0.07 | -0.16 (p = 0.01) | 0.09 | 0.09 | 0.04 | -0.12 | 0.02 |
| cg16006965 (GCET2) | 0.05 | 0.01 | -0.10 | 0.17 (p = 0.01) | 0.07 | 0.09 | -0.07 | 0.04 |
| Candidate gene follow-up analyses | ||||||||
| cg01225698 (BDNF) | -0.10 | 0.08 | 0.05 | -0.03 | -0.02 | 0.04 | 0.03 | 0.02 |
| cg18354203 (BDNF) | 0.06 | -0.12 | -0.09 | 0.00 | -0.01 | -0.03 | -0.06 | 0.07 |
| cg07061368 (FKBP5) | 0.00 | -0.03 | -0.08 | 0.20 (p = 0.001) a | 0.11 | 0.08 | -0.03 | 0.10 |
| cg05443523 (MAOA) | -0.09 | 0.10 | 0.03 | -0.09 | -0.13 (p = 0.001) a | -0.02 | -0.01 | -0.04 |
N.B. All associations control for sex and cell-type.
a
Association remains significant after additionally controlling for other exposures, p<0.05